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No one knows exactly what causes it, but it can occur for a variety of reasons. Some people experience depression during a serious medical illness. American psychiatric association practice guideline for the treatment of patients with major depression,2000. The causes and risk factors for depression in adults are complex and not fully understood. Researchers suggest that an adults vulnerability to depression arises out of both genetic and environmental factors. depression is a serious medical condition and people usually arent able to just get over a depressive state. It can occur for a variety of reasons and it has many different triggers. For some people, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause. depression is one of the most common mental disorders in the united states. It can affect anyone at almost any age, but the reasons some people become depressed are not always known. Researchers suspect there are actually many different causes of depression and that it is not always preventable. When depression occurs in men, it may be masked by unhealthy coping behavior. For a number of reasons, male depression often goes undiagnosed and can have devastating consequences when it goes untreated. A person with depression cannot simply snap out of itit is a medical condition that affects your quality of life. Depression can also lead to suicide, particularly if left untreated, and you are more likely to develop a physical illness if you have depression. The good news is that, in most cases, depression is treatable in older adults. nimh identifies 5 common causes of depression in older adults genes people with a family history of depression are more likely to develop it. In older adults, those who had depression when they were younger are more at risk to develop depression later in life.